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Bank of America

June 8, 2026

US Biopharmaceuticals: Is It Time To Reassess Biopharma

Sector ReportEquitiesHealth Care

The US Biopharma sector shows signs of fundamental improvement and easing regulatory headwinds, supported by attractive valuations relative to the S&P 500. Investors are increasingly reconsidering the sector as long-only exposure normalizes and hedge fund positioning begins to recover.

Key Takeaways

  • 1.Biopharma sector fundamentals are showing signs of improvement despite ongoing concerns regarding rates and structural health care headwinds.
  • 2.Policy and regulatory risks for Biopharma are easing, with FDA approvals on track and valuation remaining attractive relative to the S&P 500.
  • 3.Market positioning is turning constructive, with long-only exposure normalizing and hedge funds beginning to exit three-year low positions.

Table of Contents

  • Industry Overview
  • Fundamentals improving... but are we there yet?
  • Policy/ regulatory risks easing with Biopharma also cheap
  • Positioning turning but there's much to go to catch up
  • Disclosures

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Authors

Jason ZemanskyJacqueline PlessetSavita Subramanian

Securities

S&P 500

Themes

Biopharma RecoverySector Valuation DiscountInstitutional Positioning

Regions

North AmericaUnited States